How do I convert mg to units on a U-100 syringe?

A U-100 insulin syringe is graduated for 100 units = 1 mL. So Units = (Dose mg / Vial concentration mg per mL) × 100. Example: a 5 mg vial reconstituted in 2 mL gives 2.5 mg/mL. A 0.25 mg dose = 0.1 mL = 10 units on the syringe.

What is the standard semaglutide titration schedule?

Standard FDA-approved titration for Wegovy: weeks 1–4 = 0.25 mg/week, weeks 5–8 = 0.5 mg, weeks 9–12 = 1.0 mg, weeks 13–16 = 1.7 mg, week 17+ = 2.4 mg maintenance. Slower escalation (8 weeks per step) reduces nausea. Wegovy HD (7.2 mg) titrates to higher maintenance after 2.4 mg tolerance is established.

What is the tirzepatide titration schedule?

Standard Mounjaro/Zepbound titration: weeks 1–4 = 2.5 mg/week, weeks 5–8 = 5.0 mg, weeks 9–12 = 7.5 mg, weeks 13–16 = 10 mg, weeks 17–20 = 12.5 mg, week 21+ = 15 mg maintenance. Many clinicians stay at the lowest tolerated dose that's still producing weight loss to minimise side effects and cost.

How long does semaglutide last in the body?

Semaglutide has a half-life of ~7 days, so it requires once-weekly dosing. Steady-state plasma levels are reached after about 4–5 weeks (5 half-lives). Tirzepatide has a similar 5-day half-life, also dosed weekly. Missing one dose drops levels meaningfully — take it as soon as remembered if within 5 days of the missed dose, otherwise skip and resume next scheduled day.

Is this calculator safe to use for compounded vials?

It does the maths correctly — but you must verify the actual concentration on YOUR vial label and confirm the calculation with your prescriber or pharmacist before injecting. Compounded GLP-1s carry additional risks of contamination, mis-dosing and counterfeit products. The FDA has issued warnings about compounded semaglutide/tirzepatide. Brand-name Wegovy/Ozempic/Mounjaro/Zepbound pens have built-in dose dials and are safer where available.

💊 司美格鲁肽与替西帕肽剂量计算器

将您的处方剂量(mg)转换为复合制剂瓶 U-100 胰岛素注射器上的单位数。包括标准滴定计划供参考。

药物

处方剂量(每周 mg)

药瓶强度（每瓶毫克数）

复溶体积（加入的BAC水量，单位mL）

⚠️ 非医疗建议。 这只是一个数学工具。在注射前，请务必核对您具体瓶签上的浓度，并与您的处方医生和药剂师确认剂量。FDA已对复合司美格鲁肽/替泽帕肽的质量发出警告。有内置剂量刻度盘的品牌笔在可获得的情况下更安全。切勿从不受监管的供应商处购买。

了解U-100注射器

U-100 insulin syringe的刻度设计使得100 units = 1 mL。因此注射器上的一个「单位」刻度 = 0.01毫升。数学很简单：

Concentration (mg/mL) = vial mg ÷ recon volume mL
Volume per dose (mL) = prescribed mg ÷ concentration
Units on U-100 syringe = volume mL × 100

示例演示

您有5 mg vial of semaglutide，用2 mL of bacteriostatic water重新配制。您的处方写明0.25 mg/week：

浓度 = 5 ÷ 2 = 2.5 mg/mL
每次剂量体积 = 0.25 ÷ 2.5 = 0.10 mL
U-100胰岛素单位数 = 0.10 × 100 = 10 units
每瓶剂量数 = 5 ÷ 0.25 = 20 doses

司美格鲁肽标准滴定方案（Wegovy）

FDA 批准的递增,每 4 周增加剂量:

Weeks 1–4: 0.25 毫克/周
Weeks 5–8: 0.50 毫克/周
Weeks 9–12: 1.0 mg/周
Weeks 13–16: 1.7 mg/周
Week 17+: 2.4 毫克/周维持剂量（或进一步升级时使用7.2毫克Wegovy高剂量）

替尔泊肽标准剂量递增方案（Mounjaro / Zepbound）

Weeks 1–4: 2.5 毫克/周
Weeks 5–8: 5.0 mg/周
Weeks 9–12: 7.5 mg/周
Weeks 13–16: 10 mg/周
Weeks 17–20: 12.5毫克/周
Week 21+: 15毫克/周维持剂量

放缓剂量调整以减少副作用

如果恶心、呕吐或便秘严重，许多临床医生会在升级剂量前将每个剂量水平延长至 6–8 weeks。耐受性通常会随时间改善。降回前一个剂量2-4周是有效的恢复方案——只需与您的处方医生沟通。

储存和处理

储存复配药瓶 refrigerated (2–8°C / 36–46°F)
重新配制后在 28 days 内使用(司美格鲁肽);请向您的复配商确认 BUD
请勿冷冻；如已冷冻，请丢弃
每次使用前检查——如浑浊、变色或含有颗粒，请丢弃

⚠️

重要提示： 此计算器不能替代专业医疗建议。复合GLP-1药物的浓度和质量差异很大。请务必核对您具体瓶签上的实际标注，与处方医生确认剂量计划，切勿自行增加剂量。FDA已记录多起复合GLP-1产品的不良事件，包括剂量错误、污染和假冒成分。